IQCG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007288Biological processsperm axoneme assembly
GO_0044782Biological processcilium organization
GO_0007286Biological processspermatid development
GO_0031514Cellular componentmotile cilium
GO_0015629Cellular componentactin cytoskeleton
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0036126Cellular componentsperm flagellum
GO_0002177Cellular componentmanchette
GO_0005737Cellular componentcytoplasm
GO_0005516Molecular functioncalmodulin binding
GO_0030544Molecular functionHsp70 protein binding

IV. Literature review

[source]
Gene nameIQCG
Protein nameDynein regulatory complex protein 9 (IQ domain-containing protein G)
IQ motif containing G
SynonymsDRC9
DescriptionFUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. .

AccessionsC9JUC1
ENST00000453254.5
B9EG57
ENST00000452735.1
ENST00000455191.5 [Q9H095-1]
ENST00000416896.1
ENST00000265239.11 [Q9H095-1]
C9JKX8
C9J6M9
Q9H095