IPO4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IPO4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IPO4 at tissue level.

III. Associated gene sets

GO_0034504Biological processprotein localization to nucleus
GO_0006606Biological processprotein import into nucleus
GO_0032991Cellular componentprotein-containing complex
GO_0000785Cellular componentchromatin
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008139Molecular functionnuclear localization sequence binding
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0061608Molecular functionnuclear import signal receptor activity

IV. Literature review

[source]
Gene nameIPO4
Protein nameImportin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)
IPO4 protein
Importin 4
SynonymsIMP4B
RANBP4
DescriptionFUNCTION: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR . Serves as receptor for nuclear localization signals (NLS) in cargo substrates . Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism . At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran . The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus . Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B) . Mediates the ligand-independent nuclear import of vitamin D receptor (VDR) . In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS . .

AccessionsENST00000559253.1
ENST00000561034.1
ENST00000561462.5
H0YLV0
ENST00000625289.1
H0YK93
H0YN14
H0YMR4
ENST00000558233.1
ENST00000560155.5
ENST00000354464.11 [Q8TEX9-1]
H0YKG5
Q6I9Y8
Q8TEX9
ENST00000644546.2 [Q8TEX9-1]
ENST00000558046.5
ENST00000558780.5
H0YN07
H0YL92