IPO11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006610Biological processribosomal protein import into nucleus
GO_0006606Biological processprotein import into nucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005635Cellular componentnuclear envelope
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0061608Molecular functionnuclear import signal receptor activity

IV. Literature review

[source]
Gene nameIPO11
Protein nameImportin-11 (Imp11) (Ran-binding protein 11) (RanBP11)
Importin 11
SynonymsRANBP11
DescriptionFUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). .

AccessionsF8WBN4
ENST00000511713.5
D6RJB1
D6RCQ2
Q9UI26
ENST00000409296.7 [Q9UI26-2]
ENST00000409534.1
H0Y8M5
ENST00000505902.5
E7EMB7
ENST00000514647.5
ENST00000325324.11 [Q9UI26-1]
ENST00000506200.5
ENST00000413749.2
ENST00000424533.5
D6RCN7
F8WDV0