IL4I1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL4I1 at tissue level.

III. Associated gene sets

GO_0045577Biological processregulation of B cell differentiation
GO_0002841Biological processnegative regulation of T cell mediated immune response to tumor cell
GO_0006559Biological processL-phenylalanine catabolic process
GO_0019440Biological processtryptophan catabolic process to indole-3-acetate
GO_0009063Biological processamino acid catabolic process
GO_0050868Biological processnegative regulation of T cell activation
GO_0002819Biological processregulation of adaptive immune response
GO_0006569Biological processtryptophan catabolic process
GO_0002250Biological processadaptive immune response
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0045591Biological processpositive regulation of regulatory T cell differentiation
GO_0006572Biological processtyrosine catabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001772Cellular componentimmunological synapse
GO_0001669Cellular componentacrosomal vesicle
GO_0005576Cellular componentextracellular region
GO_0005764Cellular componentlysosome
GO_0097225Cellular componentsperm midpiece
GO_0046592Molecular functionpolyamine oxidase activity
GO_0001716Molecular functionL-amino-acid oxidase activity
GO_0106329Molecular functionL-phenylalaine oxidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIL4I1
Protein nameAmine oxidase (EC 1.4.3.-)
Interleukin 4 induced 1
L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (EC 1.4.3.25) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (hIL4I1) (Protein Fig-1) (hFIG1)
SynonymsFIG1
UNQ636/PRO1265
DescriptionFUNCTION: Secreted L-amino-acid oxidase that acts as a key immunoregulator . Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively . Also has weak L-arginine oxidase activity . Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR . IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer . AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity . Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells . Also regulates M2 macrophage polarization by inhibiting T-cell activation (By similarity). Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 . .

AccessionsM0QYW8
ENST00000596011.1
ENST00000341114.7 [Q96RQ9-2]
ENST00000391826.7 [Q96RQ9-1]
Q96RQ9
ENST00000601717.5
M0QYH9
ENST00000593956.5
ENST00000596022.5
ENST00000595948.5 [Q96RQ9-2]
M0QXY7
ENST00000597295.5
M0R2S9
A2RRH1
M0R1L1