IL22RA1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL22RA1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL22RA1 at tissue level.

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0050728Biological processnegative regulation of inflammatory response
GO_0008150Biological processbiological_process
GO_0140865Biological processinterleukin-22-mediated signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0042018Molecular functioninterleukin-22 receptor activity
GO_0004904Molecular functioninterferon receptor activity
GO_0042015Molecular functioninterleukin-20 binding
GO_0005515Molecular functionprotein binding
GO_0004896Molecular functioncytokine receptor activity

IV. Literature review

[source]
Gene nameIL22RA1
Protein nameInterleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11)
SynonymsIL22R
DescriptionFUNCTION: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. .

AccessionsENST00000270800.2
Q8N6P7