IFNLR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IFNLR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IFNLR1 at tissue level.

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0098586Biological processcellular response to virus
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0050691Biological processregulation of defense response to virus by host
GO_0038196Biological processtype III interferon-mediated signaling pathway
GO_0002385Biological processmucosal immune response
GO_1901857Biological processpositive regulation of cellular respiration
GO_0034342Biological processresponse to type III interferon
GO_0032002Cellular componentinterleukin-28 receptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding
GO_0004896Molecular functioncytokine receptor activity

IV. Literature review

[source]
Gene nameIFNLR1
Protein nameInterferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
Interferon lambda receptor 1
SynonymsIL28RA
LICR2
DescriptionFUNCTION: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. .

AccessionsENST00000374421.7 [Q8IU57-2]
ENST00000374419.1
ENST00000327575.6 [Q8IU57-4]
Q8IU57
Q5VTX9
ENST00000374418.3 [Q8IU57-3]
ENST00000327535.6 [Q8IU57-1]