IFIT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0045071Biological processnegative regulation of viral genome replication
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0032091Biological processnegative regulation of protein binding
GO_0019060Biological processintracellular transport of viral protein in host cell
GO_0071357Biological processcellular response to type I interferon
GO_0051097Biological processnegative regulation of helicase activity
GO_0140374Biological processantiviral innate immune response
GO_0045070Biological processpositive regulation of viral genome replication
GO_0043657Cellular componenthost cell
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameIFIT1
Protein nameInterferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56)
SynonymsIFI56
G10P1
IFNAI1
ISG56
DescriptionFUNCTION: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. .

AccessionsP09914
ENST00000546318.2 [P09914-2]
ENST00000371804.4 [P09914-1]