Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 16 studies | 33% ± 14% | |
natural killer cell | 10 studies | 33% ± 14% | |
monocyte | 10 studies | 29% ± 16% | |
conventional dendritic cell | 9 studies | 32% ± 13% | |
smooth muscle cell | 7 studies | 20% ± 3% | |
fibroblast | 7 studies | 22% ± 5% | |
non-classical monocyte | 6 studies | 25% ± 8% | |
CD4-positive, alpha-beta T cell | 6 studies | 25% ± 10% | |
endothelial cell | 6 studies | 20% ± 3% | |
T cell | 6 studies | 24% ± 5% | |
B cell | 5 studies | 28% ± 9% | |
CD8-positive, alpha-beta T cell | 5 studies | 23% ± 8% | |
plasma cell | 4 studies | 25% ± 3% | |
classical monocyte | 4 studies | 21% ± 1% | |
mature NK T cell | 4 studies | 24% ± 6% | |
connective tissue cell | 4 studies | 20% ± 4% | |
dendritic cell | 4 studies | 35% ± 19% | |
innate lymphoid cell | 3 studies | 29% ± 8% | |
myeloid cell | 3 studies | 19% ± 2% | |
intermediate monocyte | 3 studies | 26% ± 4% | |
pericyte | 3 studies | 30% ± 14% | |
leukocyte | 3 studies | 35% ± 15% | |
gamma-delta T cell | 3 studies | 35% ± 15% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
kidney | 4 studies | 27% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 95% | 7459.13 | 551 / 578 | 89% | 22.48 | 1024 / 1155 |
kidney | 70% | 1943.26 | 62 / 89 | 78% | 9.50 | 706 / 901 |
bladder | 43% | 1709.52 | 9 / 21 | 82% | 17.69 | 413 / 504 |
skin | 20% | 275.80 | 355 / 1809 | 95% | 29.28 | 449 / 472 |
breast | 22% | 180.37 | 102 / 459 | 87% | 13.42 | 973 / 1118 |
uterus | 16% | 330.09 | 28 / 170 | 89% | 40.83 | 410 / 459 |
esophagus | 24% | 457.14 | 347 / 1445 | 78% | 38.44 | 143 / 183 |
adrenal gland | 62% | 1068.10 | 160 / 258 | 37% | 10.92 | 86 / 230 |
spleen | 99% | 5707.32 | 238 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 18.63 | 43 / 45 |
liver | 47% | 1788.56 | 106 / 226 | 48% | 11.05 | 194 / 406 |
pancreas | 9% | 160.14 | 30 / 328 | 84% | 40.89 | 150 / 178 |
stomach | 32% | 1923.62 | 115 / 359 | 59% | 5.33 | 169 / 286 |
peripheral blood | 90% | 20945.27 | 833 / 929 | 0% | 0 | 0 / 0 |
intestine | 28% | 536.87 | 271 / 966 | 60% | 11.03 | 318 / 527 |
ovary | 23% | 2958.66 | 42 / 180 | 63% | 5.51 | 273 / 430 |
brain | 29% | 2270.37 | 760 / 2642 | 56% | 15.31 | 392 / 705 |
thymus | 40% | 1108.64 | 259 / 653 | 43% | 4.15 | 260 / 605 |
lymph node | 0% | 0 | 0 / 0 | 62% | 5.55 | 18 / 29 |
adipose | 61% | 1106.80 | 737 / 1204 | 0% | 0 | 0 / 0 |
prostate | 26% | 195.80 | 64 / 245 | 25% | 5.11 | 128 / 502 |
blood vessel | 41% | 1225.84 | 543 / 1335 | 0% | 0 | 0 / 0 |
heart | 38% | 1188.78 | 330 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 34% | 5.25 | 27 / 80 |
muscle | 2% | 143.07 | 19 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006986 | Biological process | response to unfolded protein |
GO_0034605 | Biological process | cellular response to heat |
GO_0070370 | Biological process | cellular heat acclimation |
GO_0042026 | Biological process | protein refolding |
GO_0051085 | Biological process | chaperone cofactor-dependent protein refolding |
GO_0005576 | Cellular component | extracellular region |
GO_0070062 | Cellular component | extracellular exosome |
GO_0034774 | Cellular component | secretory granule lumen |
GO_0005814 | Cellular component | centriole |
GO_0072562 | Cellular component | blood microparticle |
GO_1904813 | Cellular component | ficolin-1-rich granule lumen |
GO_0005829 | Cellular component | cytosol |
GO_0008180 | Cellular component | COP9 signalosome |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0044183 | Molecular function | protein folding chaperone |
GO_0031072 | Molecular function | heat shock protein binding |
GO_0051082 | Molecular function | unfolded protein binding |
GO_0140662 | Molecular function | ATP-dependent protein folding chaperone |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | HSPA6 |
Protein name | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') |
Synonyms | HSP70B' |
Description | FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release . . |
Accessions | ENST00000309758.6 P17066 |