HSPA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090084Biological processnegative regulation of inclusion body assembly
GO_0006986Biological processresponse to unfolded protein
GO_0009408Biological processresponse to heat
GO_0007283Biological processspermatogenesis
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0007286Biological processspermatid development
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0007141Biological processmale meiosis I
GO_0009409Biological processresponse to cold
GO_0042026Biological processprotein refolding
GO_0070194Biological processsynaptonemal complex disassembly
GO_0051085Biological processchaperone cofactor-dependent protein refolding
GO_0007140Biological processmale meiotic nuclear division
GO_0000795Cellular componentsynaptonemal complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0036128Cellular componentCatSper complex
GO_0072562Cellular componentblood microparticle
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0072687Cellular componentmeiotic spindle
GO_0001673Cellular componentmale germ cell nucleus
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0051861Molecular functionglycolipid binding
GO_0044183Molecular functionprotein folding chaperone
GO_0031072Molecular functionheat shock protein binding
GO_0051082Molecular functionunfolded protein binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0140662Molecular functionATP-dependent protein folding chaperone
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0097718Molecular functiondisordered domain specific binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameHSPA2
Protein nameHeat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2)
Synonyms
DescriptionFUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release . Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). .

AccessionsENST00000394709.2
P54652
ENST00000247207.7