HSD3B2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HSD3B2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HSD3B2 at tissue level.

III. Associated gene sets

GO_0021766Biological processhippocampus development
GO_0006694Biological processsteroid biosynthetic process
GO_0008207Biological processC21-steroid hormone metabolic process
GO_0006702Biological processandrogen biosynthetic process
GO_0051412Biological processresponse to corticosterone
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005743Cellular componentmitochondrial inner membrane
GO_0045171Cellular componentintercellular bridge
GO_0030868Cellular componentsmooth endoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0003854Molecular function3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity
GO_0004769Molecular functionsteroid delta-isomerase activity
GO_0005515Molecular functionprotein binding
GO_0016616Molecular functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

IV. Literature review

[source]
Gene nameHSD3B2
Protein nameHydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)]
SynonymsHSDB3B
DescriptionFUNCTION: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. .

AccessionsENST00000369416.4 [P26439-1]
Q5QP01
ENST00000433745.5
ENST00000543831.5 [P26439-1]
P26439