HSD3B1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HSD3B1 at tissue level.

III. Associated gene sets

GO_0006703Biological processestrogen biosynthetic process
GO_0021766Biological processhippocampus development
GO_0006694Biological processsteroid biosynthetic process
GO_0008207Biological processC21-steroid hormone metabolic process
GO_0006702Biological processandrogen biosynthetic process
GO_0051412Biological processresponse to corticosterone
GO_0005730Cellular componentnucleolus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005743Cellular componentmitochondrial inner membrane
GO_0045171Cellular componentintercellular bridge
GO_0030868Cellular componentsmooth endoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0047024Molecular function5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO_0003854Molecular function3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity
GO_0004769Molecular functionsteroid delta-isomerase activity
GO_0000253Molecular function3-keto sterol reductase activity
GO_0005515Molecular functionprotein binding
GO_0016616Molecular functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

IV. Literature review

[source]
Gene nameHSD3B1
Protein name3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1) (Trophoblast antigen FDO161G)
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
SynonymsHSDB3A
3BH
DescriptionFUNCTION: A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone . Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable). .

AccessionsENST00000369413.8
ENST00000531340.5
P14060
ENST00000528909.1
E9PRN7