HSD17B8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HSD17B8 at tissue level.

III. Associated gene sets

GO_0006703Biological processestrogen biosynthetic process
GO_0006633Biological processfatty acid biosynthetic process
GO_0008209Biological processandrogen metabolic process
GO_0051290Biological processprotein heterotetramerization
GO_0005740Cellular componentmitochondrial envelope
GO_1990204Cellular componentoxidoreductase complex
GO_0005886Cellular componentplasma membrane
GO_0005759Cellular componentmitochondrial matrix
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0106386Molecular function(3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO_0047035Molecular functiontestosterone dehydrogenase (NAD+) activity
GO_0005515Molecular functionprotein binding
GO_0070404Molecular functionNADH binding

IV. Literature review

[source]
Gene nameHSD17B8
Protein name(3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Estradiol 17-beta-dehydrogenase 8) (EC 1.1.1.62) (Protein Ke6) (Ke6) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
SynonymsSDR30C1
HKE6
FABGL
RING2
DescriptionFUNCTION: Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function . Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+) . Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (Probable) . NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol . .

AccessionsQ92506
ENST00000427295.2
ENST00000230236.4
ENST00000454191.2
ENST00000374662.4
ENST00000414463.2
ENST00000422433.2