I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 3 studies | 25% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 3 studies | 25% ± 12% |
Insufficient scRNA-seq data for expression of HSD17B13 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 8913.00 | 226 / 226 | 72% | 119.69 | 293 / 406 |
| prostate | 92% | 542.41 | 226 / 245 | 56% | 5.76 | 282 / 502 |
| lung | 94% | 180.80 | 542 / 578 | 28% | 2.98 | 320 / 1155 |
| uterus | 98% | 313.44 | 166 / 170 | 16% | 1.13 | 72 / 459 |
| bladder | 90% | 130.00 | 19 / 21 | 17% | 0.85 | 84 / 504 |
| breast | 98% | 748.53 | 450 / 459 | 8% | 0.18 | 93 / 1118 |
| pancreas | 72% | 120.94 | 235 / 328 | 33% | 0.68 | 58 / 178 |
| adipose | 98% | 574.96 | 1176 / 1204 | 0% | 0 | 0 / 0 |
| intestine | 87% | 81.40 | 837 / 966 | 9% | 0.48 | 48 / 527 |
| spleen | 88% | 86.80 | 212 / 241 | 0% | 0 | 0 / 0 |
| ovary | 74% | 55.79 | 134 / 180 | 10% | 0.16 | 41 / 430 |
| skin | 68% | 254.83 | 1223 / 1809 | 8% | 0.16 | 38 / 472 |
| brain | 57% | 76.19 | 1512 / 2642 | 17% | 0.30 | 119 / 705 |
| esophagus | 56% | 50.03 | 805 / 1445 | 13% | 0.29 | 24 / 183 |
| adrenal gland | 50% | 31.33 | 130 / 258 | 11% | 0.20 | 26 / 230 |
| blood vessel | 61% | 44.70 | 809 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 60% | 71.21 | 554 / 929 | 0% | 0 | 0 / 0 |
| kidney | 24% | 18.78 | 21 / 89 | 18% | 0.75 | 165 / 901 |
| stomach | 30% | 22.30 | 108 / 359 | 6% | 0.10 | 17 / 286 |
| thymus | 26% | 16.56 | 170 / 653 | 3% | 0.06 | 17 / 605 |
| heart | 23% | 13.77 | 196 / 861 | 0% | 0 | 0 / 0 |
| muscle | 16% | 9.73 | 126 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046889 | Biological process | positive regulation of lipid biosynthetic process |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005811 | Cellular component | lipid droplet |
| GO_0004303 | Molecular function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| GO_0016229 | Molecular function | steroid dehydrogenase activity |
| GO_0004745 | Molecular function | all-trans-retinol dehydrogenase (NAD+) activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0016616 | Molecular function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO_0003674 | Molecular function | molecular_function |
| Gene name | HSD17B13 |
| Protein name | 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.1.-) (EC 1.1.1.62) (Hepatic retinol/retinal dehydrogenase) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 16C member 3) (Short-chain dehydrogenase/reductase 9) |
| Synonyms | SCDR9 UNQ497/PRO1014 HMFN0376 SDR16C3 |
| Description | FUNCTION: Plays a pivotal role in hepatic lipid metabolism . In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4 . .; FUNCTION: [Isoform 2]: Has retinol/retinal dehydrogenase activity in vitro. .; FUNCTION: [Isoform 1]: Does not have retinol/retinal dehydrogenase activity in vitro. . |
| Accessions | ENST00000328546.5 [Q7Z5P4-1] Q7Z5P4 ENST00000302219.10 [Q7Z5P4-2] |
