HS3ST5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050819Biological processnegative regulation of coagulation
GO_0015015Biological processheparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO_0046596Biological processregulation of viral entry into host cell
GO_0006477Biological processprotein sulfation
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0008467Molecular function[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
GO_0050656Molecular function3'-phosphoadenosine 5'-phosphosulfate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHS3ST5
Protein nameHeparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5)
Synonyms3OST5
HS3OST5
DescriptionFUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. .

AccessionsQ8IZT8
ENST00000312719.10