HS2ST1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010467Biological processgene expression
GO_0015014Biological processheparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO_0030202Biological processheparin metabolic process
GO_0015015Biological processheparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO_0060676Biological processureteric bud formation
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0004394Molecular functionheparan sulfate 2-O-sulfotransferase activity

IV. Literature review

[source]
Gene nameHS2ST1
Protein nameHeparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2OST) (EC 2.8.2.-)
Heparan sulfate 2-O-sulfotransferase 1
SynonymsKIAA0448
HS2ST
DescriptionFUNCTION: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). .

AccessionsQ7LGA3
ENST00000690674.1
ENST00000687893.1
ENST00000693745.1
A0A8I5KUP9
ENST00000370550.10 [Q7LGA3-1]
ENST00000591456.1
ENST00000370551.8 [Q7LGA3-3]
A0A8I5KW95
A0A8I5KR52
A0A8I5QKN0
K7EP71
ENST00000689904.1