HPSE report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HPSE at tissue level.

III. Associated gene sets

GO_0030202Biological processheparin metabolic process
GO_0006029Biological processproteoglycan metabolic process
GO_0033690Biological processpositive regulation of osteoblast proliferation
GO_0007160Biological processcell-matrix adhesion
GO_0060055Biological processangiogenesis involved in wound healing
GO_0051798Biological processpositive regulation of hair follicle development
GO_0030200Biological processheparan sulfate proteoglycan catabolic process
GO_0051797Biological processregulation of hair follicle development
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0030194Biological processpositive regulation of blood coagulation
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0061028Biological processestablishment of endothelial barrier
GO_0061042Biological processvascular wound healing
GO_0071806Biological processprotein transmembrane transport
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0045121Cellular componentmembrane raft
GO_0035580Cellular componentspecific granule lumen
GO_0005764Cellular componentlysosome
GO_0005654Cellular componentnucleoplasm
GO_0031012Cellular componentextracellular matrix
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0043202Cellular componentlysosomal lumen
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0030305Molecular functionheparanase activity
GO_0045545Molecular functionsyndecan binding
GO_0004566Molecular functionbeta-glucuronidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHPSE
Protein nameHeparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]
Heparanase (EC 3.2.1.166)
Heparanase
SynonymsHSE1
HPR1
HPSE1
HPA1
HPA
HEP
DescriptionFUNCTION: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as a procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis. .

AccessionsD6RHG4
A0A7P0TBD9
ENST00000405413.6 [Q9Y251-1]
E9PFG6
ENST00000507150.5
ENST00000509906.5 [Q9Y251-4]
Q9Y251
ENST00000681769.1
D6RAQ1
ENST00000513463.1 [Q9Y251-2]
ENST00000508891.5
ENST00000311412.10 [Q9Y251-1]
ENST00000512196.5 [Q9Y251-3]