HPF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0006974Biological processDNA damage response
GO_0010835Biological processregulation of protein ADP-ribosylation
GO_0006281Biological processDNA repair
GO_0006302Biological processdouble-strand break repair
GO_0090734Cellular componentsite of DNA damage
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0072572Molecular functionpoly-ADP-D-ribose binding
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0140768Molecular functionprotein ADP-ribosyltransferase-substrate adaptor activity

IV. Literature review

[source]
Gene nameHPF1
Protein nameHistone PARylation factor 1
SynonymsC4orf27
DescriptionFUNCTION: Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response . Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins . Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks . Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage . HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2 . While HPF1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of PARP1 and PARP2 in order to limit the length of poly-ADP-ribose chains . HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 . .

AccessionsENST00000393381.3
Q9NWY4