HP | OmnibusX

Name	Number of supported studies	Average coverage
mesothelial cell	7 studies	71% ± 27%	Explore
macrophage	4 studies	54% ± 26%	Explore
endothelial cell	4 studies	64% ± 26%	Explore
endothelial cell of sinusoid	4 studies	51% ± 25%	Explore
hepatocyte	4 studies	88% ± 18%	Explore
monocyte	4 studies	17% ± 1%	Explore
cholangiocyte	3 studies	67% ± 36%	Explore
hepatic stellate cell	3 studies	66% ± 23%	Explore
classical monocyte	3 studies	27% ± 12%	Explore

Name	Number of supported studies	Average coverage
liver	4 studies	65% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	994546.72	226 / 226	95%	3192.66	385 / 406
lung	82%	3165.27	476 / 578	50%	37.48	574 / 1155
ovary	31%	246.71	56 / 180	55%	35.10	235 / 430
peripheral blood	80%	5136.88	742 / 929	0%	0	0 / 0
adipose	74%	10405.95	885 / 1204	0%	0	0 / 0
spleen	70%	2909.75	168 / 241	0%	0	0 / 0
breast	53%	1057.20	242 / 459	5%	4.47	58 / 1118
kidney	36%	493.00	32 / 89	12%	42.63	112 / 901
heart	44%	1983.61	378 / 861	0%	0	0 / 0
adrenal gland	41%	286.59	107 / 258	1%	0.37	2 / 230
blood vessel	37%	681.71	489 / 1335	0%	0	0 / 0
uterus	15%	144.33	26 / 170	13%	7.40	61 / 459
prostate	21%	199.53	52 / 245	4%	0.42	20 / 502
pancreas	9%	42.48	30 / 328	15%	8.22	27 / 178
thymus	17%	169.26	114 / 653	4%	2.19	27 / 605
bladder	10%	66.62	2 / 21	9%	6.66	43 / 504
brain	3%	17.25	74 / 2642	14%	3.91	97 / 705
stomach	13%	105.73	46 / 359	3%	0.24	8 / 286
intestine	9%	74.81	87 / 966	3%	17.59	16 / 527
esophagus	10%	95.75	146 / 1445	2%	0.31	3 / 183
skin	5%	44.67	87 / 1809	4%	0.78	20 / 472
muscle	7%	44.26	60 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.12	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0042542	Biological process	response to hydrogen peroxide
GO_0002376	Biological process	immune system process
GO_2000296	Biological process	negative regulation of hydrogen peroxide catabolic process
GO_0006953	Biological process	acute-phase response
GO_0098869	Biological process	cellular oxidant detoxification
GO_0051354	Biological process	negative regulation of oxidoreductase activity
GO_0042742	Biological process	defense response to bacterium
GO_0006952	Biological process	defense response
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0035580	Cellular component	specific granule lumen
GO_0071682	Cellular component	endocytic vesicle lumen
GO_0070062	Cellular component	extracellular exosome
GO_0031838	Cellular component	haptoglobin-hemoglobin complex
GO_0072562	Cellular component	blood microparticle
GO_1904724	Cellular component	tertiary granule lumen
GO_0016209	Molecular function	antioxidant activity
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity
GO_0030492	Molecular function	hemoglobin binding

Gene name	HP
Protein name	HP protein Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] Haptoglobin
Synonyms
Description	FUNCTION: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. .; FUNCTION: The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. .
Accessions	Q6NSB4 ENST00000568417.6 A0A0U4DJF7 ENST00000567185.7 A0A0C4DGL8 ENST00000565574.5 J3QR68 H3BS21 P00738 ENST00000564499.5 A0A0U4DKQ8 H0Y300 J3QQI8 ENST00000357763.8 J3KSV1 H3BMJ7 ENST00000355906.10 [P00738-1] ENST00000567612.2 Q14552 ENST00000398131.6 [P00738-2] A0A0U4EXB4 A0A0U4ERW6 J3QLC9 ENST00000576168.6 ENST00000570083.5 [P00738-2] J3KRH2 ENST00000569639.5 ENST00000562526.5 Q6PEJ8

HP report