HOMER2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0070885Biological processnegative regulation of calcineurin-NFAT signaling cascade
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0007216Biological processG protein-coupled glutamate receptor signaling pathway
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_2001256Biological processregulation of store-operated calcium entry
GO_0048148Biological processbehavioral response to cocaine
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0043229Cellular componentintracellular organelle
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0032426Cellular componentstereocilium tip
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0045177Cellular componentapical part of cell
GO_0035256Molecular functionG protein-coupled glutamate receptor binding
GO_0030160Molecular functionsynaptic receptor adaptor activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameHOMER2
Protein nameHomer scaffold protein 2
Homer protein homolog 2 (Homer-2) (Cupidin)
Synonyms
DescriptionFUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses . Required for normal hearing . Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA . .

AccessionsQ9NSB8
ENST00000450735.7 [Q9NSB8-2]
ENST00000304231.12 [Q9NSB8-1]
ENST00000558817.1
H0YNR9