HMX3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HMX3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HMX3 at tissue level.

III. Associated gene sets

GO_0042472Biological processinner ear morphogenesis
GO_0007420Biological processbrain development
GO_0050885Biological processneuromuscular process controlling balance
GO_0030154Biological processcell differentiation
GO_0007566Biological processembryo implantation
GO_0060135Biological processmaternal process involved in female pregnancy
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameHMX3
Protein nameHomeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1)
SynonymsNKX-5.1
NKX5-1
DescriptionFUNCTION: Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). .

AccessionsENST00000357878.7
A6NHT5