Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 7 studies | 39% ± 20% | |
astrocyte | 7 studies | 20% ± 5% | |
retinal ganglion cell | 6 studies | 45% ± 21% | |
epithelial cell | 6 studies | 35% ± 20% | |
GABAergic neuron | 6 studies | 33% ± 12% | |
oligodendrocyte precursor cell | 6 studies | 25% ± 12% | |
endothelial cell | 5 studies | 24% ± 8% | |
neuron | 4 studies | 31% ± 6% | |
basal cell | 4 studies | 24% ± 7% | |
ciliated cell | 4 studies | 34% ± 19% | |
goblet cell | 4 studies | 22% ± 3% | |
amacrine cell | 3 studies | 20% ± 1% | |
interneuron | 3 studies | 33% ± 15% | |
oligodendrocyte | 3 studies | 20% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 8 studies | 26% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 8478.18 | 258 / 258 | 98% | 88.11 | 225 / 230 |
thymus | 99% | 2633.75 | 648 / 653 | 98% | 23.52 | 592 / 605 |
stomach | 96% | 2614.55 | 346 / 359 | 99% | 38.82 | 283 / 286 |
lung | 96% | 3421.48 | 557 / 578 | 99% | 32.38 | 1140 / 1155 |
intestine | 95% | 3553.33 | 920 / 966 | 99% | 50.10 | 521 / 527 |
prostate | 96% | 1628.27 | 234 / 245 | 98% | 37.15 | 494 / 502 |
brain | 94% | 3153.07 | 2487 / 2642 | 100% | 48.31 | 703 / 705 |
liver | 97% | 3659.09 | 220 / 226 | 96% | 31.31 | 389 / 406 |
skin | 100% | 8614.62 | 1809 / 1809 | 93% | 28.77 | 439 / 472 |
uterus | 92% | 1910.46 | 157 / 170 | 99% | 36.00 | 454 / 459 |
esophagus | 90% | 4253.94 | 1307 / 1445 | 99% | 40.95 | 182 / 183 |
bladder | 90% | 1564.76 | 19 / 21 | 99% | 36.43 | 498 / 504 |
breast | 89% | 1446.37 | 409 / 459 | 99% | 36.38 | 1109 / 1118 |
kidney | 96% | 1986.82 | 85 / 89 | 88% | 16.35 | 792 / 901 |
ovary | 88% | 2017.89 | 158 / 180 | 93% | 17.04 | 402 / 430 |
pancreas | 78% | 1245.96 | 255 / 328 | 98% | 28.29 | 174 / 178 |
lymph node | 0% | 0 | 0 / 0 | 100% | 18.39 | 29 / 29 |
spleen | 100% | 2184.70 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 45.16 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.50 | 1 / 1 |
adipose | 90% | 1339.17 | 1078 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 71% | 2924.18 | 664 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 71% | 939.93 | 943 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 66% | 9.95 | 53 / 80 |
heart | 30% | 339.17 | 258 / 861 | 0% | 0 | 0 / 0 |
muscle | 8% | 78.50 | 63 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008299 | Biological process | isoprenoid biosynthetic process |
GO_0042177 | Biological process | negative regulation of protein catabolic process |
GO_0016126 | Biological process | sterol biosynthetic process |
GO_0006695 | Biological process | cholesterol biosynthetic process |
GO_0060291 | Biological process | long-term synaptic potentiation |
GO_0070372 | Biological process | regulation of ERK1 and ERK2 cascade |
GO_0050709 | Biological process | negative regulation of protein secretion |
GO_0008542 | Biological process | visual learning |
GO_1900222 | Biological process | negative regulation of amyloid-beta clearance |
GO_0015936 | Biological process | coenzyme A metabolic process |
GO_0005778 | Cellular component | peroxisomal membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0030695 | Molecular function | GTPase regulator activity |
GO_0070402 | Molecular function | NADPH binding |
GO_0004420 | Molecular function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
GO_0120225 | Molecular function | coenzyme A binding |
GO_0005515 | Molecular function | protein binding |
Gene name | HMGCR |
Protein name | hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) 3-hydroxy-3-methylglutaryl-CoA reductase 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) Alternative protein HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) |
Synonyms | |
Description | FUNCTION: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis . HMGCR is the main target of statins, a class of cholesterol-lowering drugs . . |
Accessions | ENST00000681567.1 ENST00000680940.1 [P04035-1] ENST00000681410.1 [P04035-1] ENST00000442032.2 L8E6X7 ENST00000511986.1 H0Y8K6 ENST00000287936.9 [P04035-1] ENST00000680160.1 ENST00000681271.1 [P04035-1] H0Y8F6 ENST00000509085.5 C9JKX7 A0A7P0Z481 ENST00000343975.9 [P04035-2] P04035 A0A7P0TBP1 ENST00000511206.5 [P04035-1] |