HMGCR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008299Biological processisoprenoid biosynthetic process
GO_0042177Biological processnegative regulation of protein catabolic process
GO_0016126Biological processsterol biosynthetic process
GO_0006695Biological processcholesterol biosynthetic process
GO_0060291Biological processlong-term synaptic potentiation
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0050709Biological processnegative regulation of protein secretion
GO_0008542Biological processvisual learning
GO_1900222Biological processnegative regulation of amyloid-beta clearance
GO_0015936Biological processcoenzyme A metabolic process
GO_0005778Cellular componentperoxisomal membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030695Molecular functionGTPase regulator activity
GO_0070402Molecular functionNADPH binding
GO_0004420Molecular functionhydroxymethylglutaryl-CoA reductase (NADPH) activity
GO_0120225Molecular functioncoenzyme A binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHMGCR
Protein namehydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34)
3-hydroxy-3-methylglutaryl-CoA reductase
3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
Alternative protein HMGCR
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
Synonyms
DescriptionFUNCTION: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis . HMGCR is the main target of statins, a class of cholesterol-lowering drugs . .

AccessionsENST00000681567.1
ENST00000680940.1 [P04035-1]
ENST00000681410.1 [P04035-1]
ENST00000442032.2
L8E6X7
ENST00000511986.1
H0Y8K6
ENST00000287936.9 [P04035-1]
ENST00000680160.1
ENST00000681271.1 [P04035-1]
H0Y8F6
ENST00000509085.5
C9JKX7
A0A7P0Z481
ENST00000343975.9 [P04035-2]
P04035
A0A7P0TBP1
ENST00000511206.5 [P04035-1]