HLA-DQB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HLA-DQB2 at tissue level.

III. Associated gene sets

GO_0050870Biological processpositive regulation of T cell activation
GO_0002503Biological processpeptide antigen assembly with MHC class II protein complex
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0050778Biological processpositive regulation of immune response
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0000139Cellular componentGolgi membrane
GO_0098553Cellular componentlumenal side of endoplasmic reticulum membrane
GO_0042613Cellular componentMHC class II protein complex
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0030658Cellular componenttransport vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0023026Molecular functionMHC class II protein complex binding
GO_0032395Molecular functionMHC class II receptor activity
GO_0042605Molecular functionpeptide antigen binding

IV. Literature review

[source]
Gene nameHLA-DQB2
Protein nameMHC class II antigen
MHC class II antigen DQB2
HLA class II histocompatibility antigen, DQ beta 2 chain (Major histocompatibility complex, class II, DQ beta 2) (cDNA FLJ40688 fis, clone THYMU2024185, highly similar to HLA class II histocompatibility antigen, DX beta chain)
HLA class II histocompatibility antigen, DQ beta 2 chain (HLA class II histocompatibility antigen, DX beta chain) (MHC class II antigen DQB2)
Major histocompatibility complex, class II, DQ beta 2
HLA class II histocompatibility antigen, DQ beta 2 chain
HLA class II histocompatibility antigen, DQ beta 2 chain (Major histocompatibility complex, class II, DQ beta 2)
SynonymsICRF6c-DV19.4-001
HLA-DXB
DQB2
DescriptionFUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. .

AccessionsA0A140T999
ENST00000430668.6
A0A0G2JH31
ENST00000419109.5
Q5SR05
A0A140T9U9
H0Y7Y7
ENST00000417780.2
A0A140T9S2
A0A345F7E9
ENST00000416131.5
ENST00000442043.6
ENST00000437316.7
ENST00000435145.6
I7H125
ENST00000419685.6
A2ADX3
ENST00000399661.4
ENST00000415137.6
ENST00000323109.13
ENST00000399658.7
ENST00000419519.6
A0A140T9H0
ENST00000426733.5 [P05538-2]
ENST00000447979.5
ENST00000456529.1 [P05538-2]
ENST00000435081.1
ENST00000429783.6
ENST00000411527.5 [P05538-2]
ENST00000424579.5
A0A140T9J1
ENST00000428972.2
A0A2H4Z4T9
ENST00000433114.2
ENST00000421468.5
P05538
ENST00000427449.1
ENST00000432486.6
ENST00000455520.6
ENST00000430849.6
A0A140T9F0
ENST00000433801.6
A0A2H4Z4R5
A0A140T9B0
Q5SQ91
ENST00000418419.5
A0A2H4Z4T8
ENST00000442806.6
ENST00000457432.6
ENST00000438757.1 [P05538-2]