HJURP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HJURP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HJURP at tissue level.

III. Associated gene sets

GO_0043254Biological processregulation of protein-containing complex assembly
GO_0051101Biological processregulation of DNA binding
GO_0034080Biological processCENP-A containing chromatin assembly
GO_0007059Biological processchromosome segregation
GO_0000775Cellular componentchromosome, centromeric region
GO_0005730Cellular componentnucleolus
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0003677Molecular functionDNA binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding

IV. Literature review

[source]
Gene nameHJURP
Protein nameHolliday junction recognition protein
Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9)
SynonymsFLEG1
FAKTS
URLC9
DescriptionFUNCTION: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. .

AccessionsH7C0I6
ENST00000441687.5 [Q8NCD3-3]
ENST00000433484.2
Q8NCD3
ENST00000432087.5 [Q8NCD3-2]
ENST00000453122.1
H7C3V8
ENST00000411486.7 [Q8NCD3-1]
ENST00000454020.1
F8WCV1
ENST00000414924.5
C9JWC4