I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 23% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 23% ± 2% |
Insufficient scRNA-seq data for expression of HEMK1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 5481.25 | 245 / 245 | 100% | 6.54 | 502 / 502 |
| thymus | 100% | 7457.57 | 653 / 653 | 100% | 5.91 | 603 / 605 |
| uterus | 100% | 4445.32 | 170 / 170 | 99% | 3.99 | 456 / 459 |
| bladder | 100% | 3622.14 | 21 / 21 | 99% | 4.53 | 500 / 504 |
| pancreas | 100% | 2647.24 | 327 / 328 | 99% | 3.97 | 177 / 178 |
| breast | 100% | 2760.75 | 457 / 459 | 100% | 5.32 | 1113 / 1118 |
| liver | 100% | 2735.59 | 225 / 226 | 100% | 3.19 | 404 / 406 |
| skin | 99% | 1966.00 | 1792 / 1809 | 100% | 4.55 | 472 / 472 |
| kidney | 100% | 3229.39 | 89 / 89 | 99% | 3.96 | 891 / 901 |
| intestine | 100% | 3280.62 | 966 / 966 | 99% | 3.95 | 520 / 527 |
| ovary | 100% | 5908.71 | 180 / 180 | 99% | 3.65 | 424 / 430 |
| lung | 99% | 2757.89 | 575 / 578 | 99% | 3.58 | 1143 / 1155 |
| stomach | 100% | 2614.49 | 359 / 359 | 98% | 3.29 | 280 / 286 |
| adrenal gland | 100% | 2507.35 | 258 / 258 | 95% | 2.91 | 218 / 230 |
| brain | 94% | 1071.65 | 2490 / 2642 | 100% | 4.48 | 705 / 705 |
| esophagus | 100% | 2760.00 | 1445 / 1445 | 94% | 2.20 | 172 / 183 |
| eye | 0% | 0 | 0 / 0 | 100% | 3.37 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 5.21 | 29 / 29 |
| spleen | 100% | 3375.16 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 2.75 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.63 | 1 / 1 |
| blood vessel | 100% | 2546.74 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 1942.77 | 1197 / 1204 | 0% | 0 | 0 / 0 |
| heart | 97% | 1372.54 | 835 / 861 | 0% | 0 | 0 / 0 |
| muscle | 77% | 706.05 | 622 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 77% | 1089.07 | 715 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032259 | Biological process | methylation |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0008276 | Molecular function | protein methyltransferase activity |
| GO_0003677 | Molecular function | DNA binding |
| GO_0008170 | Molecular function | N-methyltransferase activity |
| GO_0102559 | Molecular function | protein-(glutamine-N5) methyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HEMK1 |
| Protein name | HemK methyltransferase family member 1 MTRF1L release factor glutamine methyltransferase (EC 2.1.1.297) (HemK methyltransferase family member 1) (M.HsaHemKP) peptide chain release factor N(5)-glutamine methyltransferase (EC 2.1.1.297) |
| Synonyms | HEMK hCG_14983 |
| Description | FUNCTION: N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factors MTRF1, MTRF1L, MRPL58/ICT1 and MTRFR. . |
| Accessions | ENST00000448997.5 ENST00000455834.5 ENST00000443894.1 A0A140VK98 Q9Y5R4 ENST00000232854.9 ENST00000434410.5 ENST00000424388.1 H7C258 F2Z2F0 |
