HECW2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_2000650Biological processnegative regulation of sodium ion transmembrane transporter activity
GO_0048814Biological processregulation of dendrite morphogenesis
GO_0072686Cellular componentmitotic spindle
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHECW2
Protein nameHECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
SynonymsNEDL2
KIAA1301
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 . Involved in the regulation of mitotic metaphase/anaphase transition . .

AccessionsENST00000647236.1 [Q9P2P5-2]
ENST00000644030.1
A0A2R8YE75
C9JHL2
ENST00000644256.1 [Q9P2P5-1]
ENST00000260983.8 [Q9P2P5-1]
Q9P2P5
ENST00000644421.1
A0A2R8Y6F3
ENST00000427457.2
ENST00000644978.2 [Q9P2P5-1]