Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 23 studies | 36% ± 17% | |
| oligodendrocyte | 16 studies | 56% ± 19% | |
| glutamatergic neuron | 13 studies | 64% ± 24% | |
| oligodendrocyte precursor cell | 12 studies | 35% ± 13% | |
| GABAergic neuron | 11 studies | 54% ± 27% | |
| capillary endothelial cell | 11 studies | 31% ± 19% | |
| endothelial cell of lymphatic vessel | 8 studies | 43% ± 19% | |
| neuron | 6 studies | 53% ± 16% | |
| interneuron | 6 studies | 67% ± 21% | |
| retinal ganglion cell | 5 studies | 45% ± 20% | |
| cardiac muscle cell | 5 studies | 40% ± 9% | |
| granule cell | 4 studies | 61% ± 6% | |
| Mueller cell | 4 studies | 45% ± 13% | |
| endothelial cell of vascular tree | 4 studies | 24% ± 4% | |
| astrocyte | 4 studies | 35% ± 20% | |
| glomerular endothelial cell | 3 studies | 49% ± 8% | |
| GABAergic interneuron | 3 studies | 64% ± 5% | |
| microglial cell | 3 studies | 42% ± 12% | |
| vein endothelial cell | 3 studies | 19% ± 2% | |
| OFF-bipolar cell | 3 studies | 32% ± 7% | |
| ON-bipolar cell | 3 studies | 26% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 1654.03 | 2619 / 2642 | 89% | 2.83 | 627 / 705 |
| breast | 97% | 1121.13 | 444 / 459 | 85% | 2.47 | 952 / 1118 |
| lung | 100% | 4685.78 | 578 / 578 | 75% | 2.27 | 872 / 1155 |
| thymus | 100% | 1934.42 | 651 / 653 | 76% | 2.44 | 458 / 605 |
| adrenal gland | 95% | 708.74 | 244 / 258 | 75% | 2.90 | 172 / 230 |
| kidney | 90% | 674.80 | 80 / 89 | 63% | 4.65 | 566 / 901 |
| esophagus | 70% | 436.75 | 1018 / 1445 | 80% | 2.04 | 146 / 183 |
| pancreas | 31% | 113.01 | 103 / 328 | 72% | 1.85 | 129 / 178 |
| skin | 78% | 395.88 | 1403 / 1809 | 26% | 0.54 | 122 / 472 |
| stomach | 47% | 181.45 | 169 / 359 | 56% | 1.40 | 159 / 286 |
| liver | 60% | 312.03 | 135 / 226 | 41% | 0.75 | 165 / 406 |
| spleen | 100% | 2662.59 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 100% | 1496.19 | 859 / 861 | 0% | 0 | 0 / 0 |
| adipose | 97% | 1207.19 | 1172 / 1204 | 0% | 0 | 0 / 0 |
| uterus | 64% | 359.19 | 109 / 170 | 32% | 0.62 | 149 / 459 |
| blood vessel | 82% | 591.68 | 1091 / 1335 | 0% | 0 | 0 / 0 |
| intestine | 39% | 170.20 | 372 / 966 | 39% | 0.84 | 206 / 527 |
| bladder | 38% | 172.48 | 8 / 21 | 35% | 0.78 | 174 / 504 |
| prostate | 45% | 207.56 | 111 / 245 | 12% | 0.22 | 62 / 502 |
| tonsil | 0% | 0 | 0 / 0 | 51% | 1.07 | 23 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 45% | 1.00 | 13 / 29 |
| ovary | 29% | 99.27 | 52 / 180 | 13% | 0.21 | 57 / 430 |
| peripheral blood | 41% | 470.09 | 378 / 929 | 0% | 0 | 0 / 0 |
| muscle | 18% | 59.42 | 141 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0030071 | Biological process | regulation of mitotic metaphase/anaphase transition |
| GO_2000650 | Biological process | negative regulation of sodium ion transmembrane transporter activity |
| GO_0048814 | Biological process | regulation of dendrite morphogenesis |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HECW2 |
| Protein name | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) HECT-type E3 ubiquitin transferase (EC 2.3.2.26) |
| Synonyms | NEDL2 KIAA1301 |
| Description | FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 . Involved in the regulation of mitotic metaphase/anaphase transition . . |
| Accessions | ENST00000647236.1 [Q9P2P5-2] ENST00000644030.1 A0A2R8YE75 C9JHL2 ENST00000644256.1 [Q9P2P5-1] ENST00000260983.8 [Q9P2P5-1] Q9P2P5 ENST00000644421.1 A0A2R8Y6F3 ENST00000427457.2 ENST00000644978.2 [Q9P2P5-1] |