HECA report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
macrophage	11 studies	21% ± 6%	Explore
classical monocyte	9 studies	22% ± 8%	Explore
T cell	7 studies	31% ± 15%	Explore
CD4-positive, alpha-beta T cell	7 studies	21% ± 3%	Explore
endothelial cell	7 studies	20% ± 3%	Explore
non-classical monocyte	6 studies	28% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
microglial cell	5 studies	29% ± 8%	Explore
B cell	4 studies	19% ± 1%	Explore
monocyte	4 studies	20% ± 3%	Explore
natural killer cell	4 studies	19% ± 3%	Explore
squamous epithelial cell	4 studies	31% ± 17%	Explore
leukocyte	4 studies	23% ± 4%	Explore
myeloid cell	4 studies	24% ± 6%	Explore
epithelial cell	4 studies	33% ± 12%	Explore
lymphocyte	4 studies	27% ± 10%	Explore
CD8-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	26% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	25% ± 9%	Explore
mucosal invariant T cell	3 studies	20% ± 2%	Explore
gamma-delta T cell	3 studies	24% ± 5%	Explore
mature NK T cell	3 studies	22% ± 4%	Explore
regulatory T cell	3 studies	20% ± 4%	Explore
GABAergic neuron	3 studies	25% ± 3%	Explore
glutamatergic neuron	3 studies	34% ± 7%	Explore
dendritic cell	3 studies	25% ± 12%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	24% ± 5%	Explore
lung	3 studies	21% ± 6%	Explore
brain	3 studies	25% ± 5%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4049.64	459 / 459	100%	30.89	1118 / 1118
esophagus	100%	3725.79	1445 / 1445	100%	36.41	183 / 183
lung	100%	5227.89	578 / 578	100%	27.63	1154 / 1155
prostate	100%	2770.49	245 / 245	100%	21.47	501 / 502
uterus	100%	3714.08	170 / 170	100%	27.08	458 / 459
intestine	100%	3634.07	966 / 966	100%	22.00	525 / 527
bladder	100%	3274.90	21 / 21	100%	25.64	502 / 504
thymus	100%	2845.06	652 / 653	100%	20.96	603 / 605
brain	99%	1907.31	2623 / 2642	100%	23.61	702 / 705
stomach	100%	2217.17	358 / 359	99%	23.08	283 / 286
ovary	100%	4239.13	180 / 180	98%	12.83	420 / 430
adrenal gland	100%	1661.17	258 / 258	97%	15.05	223 / 230
skin	100%	4839.13	1809 / 1809	95%	15.27	449 / 472
kidney	98%	1574.18	87 / 89	96%	17.82	869 / 901
pancreas	89%	1029.06	291 / 328	99%	25.33	176 / 178
liver	88%	1006.81	200 / 226	88%	8.77	359 / 406
adipose	100%	4416.59	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4117.68	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	30.02	29 / 29
muscle	100%	3129.10	803 / 803	0%	0	0 / 0
spleen	100%	6126.76	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.14	45 / 45
ureter	0%	0	0 / 0	100%	11.42	1 / 1
heart	99%	3014.01	849 / 861	0%	0	0 / 0
peripheral blood	95%	4023.22	880 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	88%	9.38	70 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0