HCN4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HCN4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HCN4 at tissue level.

III. Associated gene sets

GO_0086012Biological processmembrane depolarization during cardiac muscle cell action potential
GO_0086015Biological processSA node cell action potential
GO_0042391Biological processregulation of membrane potential
GO_0098909Biological processregulation of cardiac muscle cell action potential involved in regulation of contraction
GO_0002027Biological processregulation of heart rate
GO_0071321Biological processcellular response to cGMP
GO_0006936Biological processmuscle contraction
GO_0071805Biological processpotassium ion transmembrane transport
GO_0003254Biological processregulation of membrane depolarization
GO_0086046Biological processmembrane depolarization during SA node cell action potential
GO_0071320Biological processcellular response to cAMP
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0008015Biological processblood circulation
GO_0098719Biological processsodium ion import across plasma membrane
GO_0006812Biological processmonoatomic cation transport
GO_0003163Biological processsinoatrial node development
GO_0055117Biological processregulation of cardiac muscle contraction
GO_0035725Biological processsodium ion transmembrane transport
GO_1990573Biological processpotassium ion import across plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030425Cellular componentdendrite
GO_0030424Cellular componentaxon
GO_0098855Cellular componentHCN channel complex
GO_0030552Molecular functioncAMP binding
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0005248Molecular functionvoltage-gated sodium channel activity
GO_0042802Molecular functionidentical protein binding
GO_0086041Molecular functionvoltage-gated potassium channel activity involved in SA node cell action potential depolarization
GO_0005222Molecular functionintracellularly cAMP-activated cation channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHCN4
Protein namePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Synonyms
DescriptionFUNCTION: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. .

AccessionsENST00000261917.4
Q9Y3Q4