HCN2 | OmnibusX

Name	Number of supported studies	Average coverage
brain	4 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	9030.46	2641 / 2642	98%	46.60	692 / 705
adrenal gland	42%	429.82	109 / 258	90%	28.46	208 / 230
heart	72%	1075.61	623 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	68%	8.43	54 / 80
skin	1%	6.30	16 / 1809	61%	15.32	286 / 472
lymph node	0%	0	0 / 0	41%	2.32	12 / 29
esophagus	3%	24.62	42 / 1445	22%	1.66	40 / 183
kidney	1%	7.73	1 / 89	15%	6.30	132 / 901
stomach	0%	0	0 / 359	15%	1.84	42 / 286
liver	0%	0	0 / 226	13%	1.07	51 / 406
breast	0%	0	0 / 459	12%	1.29	138 / 1118
lung	0%	1.68	1 / 578	12%	0.93	137 / 1155
pancreas	0%	0	0 / 328	11%	1.33	20 / 178
prostate	0%	0	0 / 245	11%	0.71	56 / 502
ovary	0%	0	0 / 180	8%	0.43	33 / 430
uterus	0%	0	0 / 170	7%	0.48	33 / 459
intestine	0%	0	0 / 966	7%	1.08	35 / 527
bladder	0%	0	0 / 21	5%	0.41	24 / 504
thymus	0%	1.32	1 / 653	3%	0.52	21 / 605
tonsil	0%	0	0 / 0	2%	0.11	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0086012	Biological process	membrane depolarization during cardiac muscle cell action potential
GO_0042391	Biological process	regulation of membrane potential
GO_0072488	Biological process	ammonium transmembrane transport
GO_0071321	Biological process	cellular response to cGMP
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0007267	Biological process	cell-cell signaling
GO_0003254	Biological process	regulation of membrane depolarization
GO_0071320	Biological process	cellular response to cAMP
GO_0098719	Biological process	sodium ion import across plasma membrane
GO_0035725	Biological process	sodium ion transmembrane transport
GO_1990573	Biological process	potassium ion import across plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0030425	Cellular component	dendrite
GO_0030424	Cellular component	axon
GO_0098855	Cellular component	HCN channel complex
GO_0008076	Cellular component	voltage-gated potassium channel complex
GO_0030552	Molecular function	cAMP binding
GO_0005249	Molecular function	voltage-gated potassium channel activity
GO_0005248	Molecular function	voltage-gated sodium channel activity
GO_0042802	Molecular function	identical protein binding
GO_0005222	Molecular function	intracellularly cAMP-activated cation channel activity
GO_0005515	Molecular function	protein binding

Gene name	HCN2
Protein name	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2)
Synonyms	BCNG2
Description	FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). .
Accessions	Q9UL51 ENST00000251287.3

HCN2 report