I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 8 studies | 22% ± 5% | |
| connective tissue cell | 4 studies | 22% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 8 studies | 22% ± 5% | |
| connective tissue cell | 4 studies | 22% ± 9% |
Insufficient scRNA-seq data for expression of HAS2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 95% | 2109.27 | 1726 / 1809 | 89% | 27.36 | 418 / 472 |
| intestine | 92% | 332.44 | 890 / 966 | 77% | 6.33 | 408 / 527 |
| lung | 89% | 747.43 | 514 / 578 | 77% | 7.85 | 892 / 1155 |
| esophagus | 78% | 228.48 | 1123 / 1445 | 73% | 6.93 | 134 / 183 |
| breast | 76% | 398.90 | 350 / 459 | 73% | 5.20 | 813 / 1118 |
| stomach | 70% | 188.65 | 253 / 359 | 77% | 5.96 | 221 / 286 |
| bladder | 62% | 434.29 | 13 / 21 | 71% | 9.94 | 360 / 504 |
| brain | 20% | 29.93 | 530 / 2642 | 82% | 9.77 | 576 / 705 |
| ureter | 0% | 0 | 0 / 0 | 100% | 11.84 | 1 / 1 |
| uterus | 42% | 73.16 | 71 / 170 | 58% | 10.06 | 267 / 459 |
| adipose | 97% | 863.54 | 1169 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 9% | 15.45 | 31 / 328 | 82% | 8.86 | 146 / 178 |
| thymus | 61% | 159.31 | 400 / 653 | 30% | 2.82 | 181 / 605 |
| heart | 89% | 413.42 | 763 / 861 | 0% | 0 | 0 / 0 |
| prostate | 72% | 243.71 | 177 / 245 | 16% | 0.60 | 79 / 502 |
| blood vessel | 66% | 266.75 | 877 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 16% | 38.74 | 29 / 180 | 47% | 2.99 | 201 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 5.41 | 27 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 2.96 | 14 / 29 |
| kidney | 33% | 62.12 | 29 / 89 | 10% | 0.76 | 91 / 901 |
| adrenal gland | 31% | 46.13 | 79 / 258 | 10% | 1.21 | 22 / 230 |
| muscle | 23% | 35.11 | 182 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 19% | 2.36 | 15 / 80 |
| liver | 7% | 17.44 | 15 / 226 | 11% | 1.01 | 43 / 406 |
| spleen | 0% | 1.00 | 1 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.15 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0044849 | Biological process | estrous cycle |
| GO_0060349 | Biological process | bone morphogenesis |
| GO_0071498 | Biological process | cellular response to fluid shear stress |
| GO_0085029 | Biological process | extracellular matrix assembly |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0001822 | Biological process | kidney development |
| GO_0071347 | Biological process | cellular response to interleukin-1 |
| GO_0045226 | Biological process | extracellular polysaccharide biosynthetic process |
| GO_0010838 | Biological process | positive regulation of keratinocyte proliferation |
| GO_1901201 | Biological process | regulation of extracellular matrix assembly |
| GO_0014911 | Biological process | positive regulation of smooth muscle cell migration |
| GO_0071356 | Biological process | cellular response to tumor necrosis factor |
| GO_0070295 | Biological process | renal water absorption |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0051549 | Biological process | positive regulation of keratinocyte migration |
| GO_0036302 | Biological process | atrioventricular canal development |
| GO_1900026 | Biological process | positive regulation of substrate adhesion-dependent cell spreading |
| GO_1900625 | Biological process | positive regulation of monocyte aggregation |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0030213 | Biological process | hyaluronan biosynthetic process |
| GO_1900127 | Biological process | positive regulation of hyaluronan biosynthetic process |
| GO_0035810 | Biological process | positive regulation of urine volume |
| GO_0036120 | Biological process | cellular response to platelet-derived growth factor stimulus |
| GO_0090500 | Biological process | endocardial cushion to mesenchymal transition |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_1903561 | Cellular component | extracellular vesicle |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0044853 | Cellular component | plasma membrane raft |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0050501 | Molecular function | hyaluronan synthase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HAS2 |
| Protein name | Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid synthase 2) (HA synthase 2) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation . This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity). . |
| Accessions | Q92819 ENST00000303924.5 |
