HARS2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HARS2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HARS2 at tissue level.

III. Associated gene sets

GO_0006412Biological processtranslation
GO_0006427Biological processhistidyl-tRNA aminoacylation
GO_0006418Biological processtRNA aminoacylation for protein translation
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0004821Molecular functionhistidine-tRNA ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameHARS2
Protein namehistidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase)
Histidyl-tRNA synthetase
Histidyl-tRNA synthetase 2, mitochondrial
Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS)
SynonymsHO3
HARSL
HARSR
DescriptionFUNCTION: Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). .

AccessionsB4DQ67
ENST00000448069.2
A0A2R8Y6I1
D6RJE6
ENST00000509299.6
ENST00000645749.1 [P49590-1]
P49590
ENST00000642452.1
D6R9M5
ENST00000510104.5
ENST00000520095.6
A0A2R8Y3N3
A0A2R8Y5P7
ENST00000230771.9 [P49590-1]
A0A2R8Y4X6
ENST00000503873.6
ENST00000643996.1
A0A2R8Y5E8
D6RB22
ENST00000647484.1
ENST00000646468.1
ENST00000642970.1
ENST00000508522.5 [P49590-2]
ENST00000645065.1
ENST00000642752.1