HAPSTR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0080135Biological processregulation of cellular response to stress
GO_1901797Biological processnegative regulation of signal transduction by p53 class mediator
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHAPSTR1
Protein nameHUWE1 associated protein modifying stress responses
HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein)
SynonymsC16orf72
TAPR1
DescriptionFUNCTION: Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs . Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage . May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 . .

AccessionsENST00000574285.2
ENST00000327827.12 [Q14CZ0-1]
Q14CZ0
A0A087X1J2