Name | Number of supported studies | Average coverage | |
---|---|---|---|
adipocyte | 9 studies | 33% ± 11% | |
ciliated cell | 7 studies | 29% ± 9% | |
epithelial cell of proximal tubule | 6 studies | 29% ± 10% | |
macrophage | 6 studies | 20% ± 6% | |
enterocyte | 6 studies | 34% ± 8% | |
smooth muscle cell | 6 studies | 19% ± 3% | |
epithelial cell | 6 studies | 46% ± 17% | |
plasmacytoid dendritic cell | 6 studies | 26% ± 11% | |
transit amplifying cell | 5 studies | 32% ± 12% | |
hematopoietic precursor cell | 4 studies | 23% ± 6% | |
type B pancreatic cell | 4 studies | 72% ± 18% | |
erythroblast | 4 studies | 28% ± 15% | |
fibroblast | 4 studies | 22% ± 4% | |
hepatocyte | 4 studies | 36% ± 17% | |
plasmablast | 3 studies | 40% ± 10% | |
pancreatic D cell | 3 studies | 53% ± 27% | |
kidney loop of Henle epithelial cell | 3 studies | 20% ± 3% | |
intestinal crypt stem cell | 3 studies | 29% ± 9% | |
progenitor cell | 3 studies | 25% ± 6% | |
pro-B cell | 3 studies | 27% ± 4% | |
GABAergic neuron | 3 studies | 30% ± 5% | |
glutamatergic neuron | 3 studies | 36% ± 5% | |
dendritic cell | 3 studies | 26% ± 1% | |
basal cell | 3 studies | 33% ± 10% | |
connective tissue cell | 3 studies | 19% ± 3% | |
natural killer cell | 3 studies | 25% ± 5% | |
astrocyte | 3 studies | 19% ± 1% | |
pericyte | 3 studies | 21% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 4679.04 | 359 / 359 | 100% | 21.99 | 286 / 286 |
bladder | 100% | 3378.67 | 21 / 21 | 100% | 22.88 | 503 / 504 |
uterus | 100% | 4386.87 | 170 / 170 | 100% | 23.35 | 457 / 459 |
breast | 100% | 7391.86 | 459 / 459 | 100% | 23.31 | 1113 / 1118 |
ovary | 100% | 4147.66 | 180 / 180 | 100% | 16.21 | 428 / 430 |
intestine | 100% | 5726.10 | 966 / 966 | 99% | 26.31 | 524 / 527 |
liver | 100% | 7738.61 | 225 / 226 | 100% | 24.56 | 405 / 406 |
esophagus | 100% | 4482.39 | 1439 / 1445 | 99% | 13.41 | 182 / 183 |
prostate | 99% | 2757.19 | 243 / 245 | 100% | 21.64 | 501 / 502 |
thymus | 99% | 2559.72 | 647 / 653 | 99% | 18.82 | 599 / 605 |
kidney | 100% | 5452.83 | 89 / 89 | 98% | 13.88 | 882 / 901 |
adrenal gland | 100% | 4946.23 | 258 / 258 | 97% | 14.97 | 224 / 230 |
skin | 99% | 2612.72 | 1787 / 1809 | 98% | 14.34 | 464 / 472 |
pancreas | 97% | 1933.71 | 318 / 328 | 99% | 15.35 | 176 / 178 |
brain | 94% | 1669.66 | 2473 / 2642 | 100% | 18.07 | 705 / 705 |
lung | 92% | 2258.17 | 533 / 578 | 100% | 15.14 | 1150 / 1155 |
adipose | 100% | 7903.09 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 14.92 | 29 / 29 |
spleen | 100% | 1911.70 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 19.86 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.87 | 1 / 1 |
blood vessel | 100% | 4710.52 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 9983.96 | 801 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 14.44 | 78 / 80 |
heart | 96% | 8034.64 | 823 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 23% | 1175.63 | 211 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0050796 | Biological process | regulation of insulin secretion |
GO_0032868 | Biological process | response to insulin |
GO_0006635 | Biological process | fatty acid beta-oxidation |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0014823 | Biological process | response to activity |
GO_0046676 | Biological process | negative regulation of insulin secretion |
GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005737 | Cellular component | cytoplasm |
GO_0005739 | Cellular component | mitochondrion |
GO_0003857 | Molecular function | 3-hydroxyacyl-CoA dehydrogenase activity |
GO_0070403 | Molecular function | NAD+ binding |
GO_0016740 | Molecular function | transferase activity |
GO_0042802 | Molecular function | identical protein binding |
Gene name | HADH |
Protein name | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) Hydroxyacyl-CoA dehydrogenase 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) |
Synonyms | HADHSC SCHAD HAD HAD1 |
Description | FUNCTION: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) . Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). . |
Accessions | A0A804HJK7 A0A804HKJ2 ENST00000639784.1 ENST00000511742.1 A0A1W2PQ78 A0A804HLB5 ENST00000639146.1 ENST00000403312.6 A0A1W2PP40 ENST00000640048.1 ENST00000682373.1 ENST00000640586.1 A0A804HJW7 ENST00000684696.1 ENST00000638559.1 E9PF18 ENST00000603302.5 [Q16836-3] ENST00000639335.1 ENST00000638648.2 Q16836 ENST00000640060.1 A0A0D9SFP2 A0A0A0MSE2 ENST00000505878.4 A0A1W2PNM1 A0A1W2PRM6 ENST00000639698.1 A0A1W2PQ55 ENST00000682067.1 J3KR89 A0A1W2PQC2 ENST00000626637.2 ENST00000309522.8 [Q16836-1] A0A1W2PQV5 ENST00000638621.1 A0A1W2PRT2 |