HADH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050796Biological processregulation of insulin secretion
GO_0032868Biological processresponse to insulin
GO_0006635Biological processfatty acid beta-oxidation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0014823Biological processresponse to activity
GO_0046676Biological processnegative regulation of insulin secretion
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0005654Cellular componentnucleoplasm
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0003857Molecular function3-hydroxyacyl-CoA dehydrogenase activity
GO_0070403Molecular functionNAD+ binding
GO_0016740Molecular functiontransferase activity
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameHADH
Protein nameHydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)
Hydroxyacyl-CoA dehydrogenase
3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)
SynonymsHADHSC
SCHAD
HAD
HAD1
DescriptionFUNCTION: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) . Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). .

AccessionsA0A804HJK7
A0A804HKJ2
ENST00000639784.1
ENST00000511742.1
A0A1W2PQ78
A0A804HLB5
ENST00000639146.1
ENST00000403312.6
A0A1W2PP40
ENST00000640048.1
ENST00000682373.1
ENST00000640586.1
A0A804HJW7
ENST00000684696.1
ENST00000638559.1
E9PF18
ENST00000603302.5 [Q16836-3]
ENST00000639335.1
ENST00000638648.2
Q16836
ENST00000640060.1
A0A0D9SFP2
A0A0A0MSE2
ENST00000505878.4
A0A1W2PNM1
A0A1W2PRM6
ENST00000639698.1
A0A1W2PQ55
ENST00000682067.1
J3KR89
A0A1W2PQC2
ENST00000626637.2
ENST00000309522.8 [Q16836-1]
A0A1W2PQV5
ENST00000638621.1
A0A1W2PRT2