HACD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0042761Biological processvery long-chain fatty acid biosynthetic process
GO_0030497Biological processfatty acid elongation
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0018812Molecular function3-hydroxyacyl-CoA dehydratase activity
GO_0102158Molecular functionvery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity

IV. Literature review

[source]
Gene nameHACD1
Protein nameVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum-attachment protein) (CAP) (Protein-tyrosine phosphatase-like member A)
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134)
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134)
Protein tyrosine phosphatase-like, member A variant 4
3-hydroxyacyl-CoA dehydratase 1
SynonymsPTPLA
DescriptionFUNCTION: [Isoform 1]: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .; FUNCTION: [Isoform 2]: In tooth development, may play a role in the recruitment and the differentiation of cells that contribute to cementum formation. May also bind hydroxyapatite and regulate its crystal nucleation to form cementum. .

FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

AccessionsENST00000466335.1
ENST00000326961.6
B0YJ83
B0YJ81
ENST00000361271.8 [B0YJ81-1]
J3KS69
ENST00000498812.5
A6NP58
J3KT94