HABP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045948Biological processpositive regulation of translational initiation
GO_0006397Biological processmRNA processing
GO_0071260Biological processcellular response to mechanical stimulus
GO_0033120Biological processpositive regulation of RNA splicing
GO_0141014Biological processribosome hibernation
GO_0030578Biological processPML body organization
GO_0008380Biological processRNA splicing
GO_0043392Biological processnegative regulation of DNA binding
GO_0005730Cellular componentnucleolus
GO_0016528Cellular componentsarcoplasm
GO_0005576Cellular componentextracellular region
GO_0016607Cellular componentnuclear speck
GO_0030017Cellular componentsarcomere
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0015030Cellular componentCajal body
GO_0097504Cellular componentGemini of coiled bodies
GO_0031965Cellular componentnuclear membrane
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0043022Molecular functionribosome binding
GO_0061770Molecular functiontranslation elongation factor binding
GO_0032183Molecular functionSUMO binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHABP4
Protein nameIntracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen)
Synonyms
DescriptionFUNCTION: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing . Binds (via C-terminus) to poly(U) RNA . Seems to play a role in PML-nuclear bodies formation . Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). .

AccessionsENST00000375249.5 [Q5JVS0-1]
ENST00000375251.7 [Q5JVS0-2]
Q5JVS0