I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 5 studies | 28% ± 9% | |
| epithelial cell | 4 studies | 26% ± 5% | |
| squamous epithelial cell | 3 studies | 29% ± 16% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 5 studies | 28% ± 9% | |
| epithelial cell | 4 studies | 26% ± 5% | |
| squamous epithelial cell | 3 studies | 29% ± 16% |
Insufficient scRNA-seq data for expression of H2BC5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 98% | 2918.73 | 240 / 245 | 100% | 198.53 | 500 / 502 |
| thymus | 99% | 653.35 | 644 / 653 | 93% | 69.35 | 560 / 605 |
| kidney | 99% | 1245.54 | 88 / 89 | 90% | 95.47 | 809 / 901 |
| liver | 100% | 948.39 | 225 / 226 | 87% | 90.18 | 354 / 406 |
| ovary | 89% | 1617.83 | 160 / 180 | 96% | 101.33 | 412 / 430 |
| lung | 92% | 634.31 | 533 / 578 | 84% | 66.77 | 969 / 1155 |
| breast | 71% | 408.37 | 327 / 459 | 96% | 184.04 | 1076 / 1118 |
| bladder | 81% | 349.14 | 17 / 21 | 85% | 75.71 | 426 / 504 |
| intestine | 88% | 547.32 | 853 / 966 | 75% | 48.52 | 396 / 527 |
| stomach | 85% | 398.97 | 305 / 359 | 77% | 42.04 | 220 / 286 |
| esophagus | 75% | 363.38 | 1086 / 1445 | 86% | 65.77 | 158 / 183 |
| skin | 91% | 563.15 | 1652 / 1809 | 69% | 49.91 | 326 / 472 |
| uterus | 64% | 898.38 | 108 / 170 | 91% | 83.11 | 417 / 459 |
| adrenal gland | 91% | 347.38 | 234 / 258 | 52% | 22.26 | 119 / 230 |
| pancreas | 51% | 147.49 | 167 / 328 | 79% | 61.30 | 141 / 178 |
| brain | 79% | 254.24 | 2099 / 2642 | 36% | 15.00 | 254 / 705 |
| ureter | 0% | 0 | 0 / 0 | 100% | 118.66 | 1 / 1 |
| peripheral blood | 99% | 955.67 | 918 / 929 | 0% | 0 | 0 / 0 |
| spleen | 99% | 717.34 | 238 / 241 | 0% | 0 | 0 / 0 |
| heart | 93% | 487.39 | 801 / 861 | 0% | 0 | 0 / 0 |
| muscle | 88% | 287.44 | 703 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 43.49 | 39 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 49.15 | 25 / 29 |
| eye | 0% | 0 | 0 / 0 | 78% | 52.52 | 62 / 80 |
| adipose | 51% | 243.38 | 611 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 46% | 151.05 | 614 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0000786 | Cellular component | nucleosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0003677 | Molecular function | DNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0030527 | Molecular function | structural constituent of chromatin |
| GO_0003674 | Molecular function | molecular_function |
| Gene name | H2BC5 |
| Protein name | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) |
| Synonyms | HIST1H2BD H2BFB HIRIP2 |
| Description | FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Accessions | ENST00000289316.2 ENST00000377777.6 P58876 |
