H2BC11 | OmnibusX

Name	Number of supported studies	Average coverage
platelet	8 studies	35% ± 9%	Explore
megakaryocyte	3 studies	31% ± 14%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of H2BC11 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	98%	145.29	240 / 245	96%	17.83	484 / 502
esophagus	83%	71.32	1201 / 1445	90%	15.91	164 / 183
lung	97%	141.96	562 / 578	68%	9.72	780 / 1155
uterus	59%	35.44	101 / 170	93%	25.73	426 / 459
bladder	76%	32.95	16 / 21	75%	17.50	378 / 504
intestine	84%	61.72	815 / 966	59%	9.12	311 / 527
skin	70%	37.69	1264 / 1809	71%	6.82	335 / 472
breast	58%	29.80	268 / 459	76%	12.50	850 / 1118
ovary	39%	18.23	71 / 180	93%	19.14	400 / 430
thymus	77%	50.59	506 / 653	52%	3.22	317 / 605
stomach	58%	47.53	208 / 359	64%	9.25	184 / 286
liver	61%	38.58	138 / 226	50%	3.91	201 / 406
spleen	100%	233.40	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	5.37	1 / 1
peripheral blood	100%	425.77	928 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	22.37	42 / 45
heart	88%	52.34	754 / 861	0%	0	0 / 0
muscle	87%	81.05	695 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	15.27	24 / 29
adrenal gland	57%	20.48	146 / 258	26%	1.67	59 / 230
blood vessel	82%	45.27	1095 / 1335	0%	0	0 / 0
brain	36%	19.55	956 / 2642	31%	2.44	220 / 705
pancreas	6%	1.82	19 / 328	59%	8.51	105 / 178
kidney	44%	32.89	39 / 89	12%	0.83	112 / 901
adipose	55%	37.55	660 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	25%	1.25	20 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006325	Biological process	chromatin organization
GO_0019731	Biological process	antibacterial humoral response
GO_0050829	Biological process	defense response to Gram-negative bacterium
GO_0006334	Biological process	nucleosome assembly
GO_0031640	Biological process	killing of cells of another organism
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0061644	Biological process	protein localization to CENP-A containing chromatin
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_0002227	Biological process	innate immune response in mucosa
GO_0010804	Biological process	negative regulation of tumor necrosis factor-mediated signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0000786	Cellular component	nucleosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0043505	Cellular component	CENP-A containing nucleosome
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0030527	Molecular function	structural constituent of chromatin
GO_0046982	Molecular function	protein heterodimerization activity
GO_0001530	Molecular function	lipopolysaccharide binding
GO_0005515	Molecular function	protein binding

Gene name	H2BC11
Protein name	H2B clustered histone 11 Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r)
Synonyms	HIST1H2BJ H2BFR
Description	FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Accessions	ENST00000607124.1 ENST00000606923.1 U3KPT8 P06899 ENST00000339812.3

H2BC11 report