Insufficient scRNA-seq data for expression of H2AC21 at single-cell level.
Insufficient scRNA-seq data for expression of H2AC21 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 81% | 4.37 | 145 / 180 | 39% | 1.41 | 166 / 430 |
| prostate | 80% | 3.23 | 196 / 245 | 28% | 0.73 | 141 / 502 |
| breast | 84% | 5.61 | 384 / 459 | 9% | 1.90 | 100 / 1118 |
| lung | 82% | 3.99 | 476 / 578 | 10% | 1.65 | 113 / 1155 |
| bladder | 76% | 2.90 | 16 / 21 | 15% | 4.30 | 76 / 504 |
| stomach | 66% | 2.80 | 236 / 359 | 20% | 1.38 | 57 / 286 |
| peripheral blood | 84% | 9.05 | 783 / 929 | 0% | 0 | 0 / 0 |
| skin | 83% | 6.35 | 1502 / 1809 | 1% | 0.01 | 5 / 472 |
| intestine | 72% | 4.45 | 698 / 966 | 8% | 1.60 | 42 / 527 |
| adipose | 78% | 3.82 | 940 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 78% | 5.27 | 187 / 241 | 0% | 0 | 0 / 0 |
| uterus | 62% | 2.12 | 106 / 170 | 10% | 1.33 | 48 / 459 |
| thymus | 66% | 2.32 | 430 / 653 | 6% | 0.12 | 38 / 605 |
| esophagus | 66% | 2.06 | 947 / 1445 | 7% | 0.12 | 12 / 183 |
| blood vessel | 69% | 2.22 | 921 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 65% | 2.22 | 521 / 803 | 0% | 0 | 0 / 0 |
| kidney | 63% | 1.89 | 56 / 89 | 1% | 0.27 | 12 / 901 |
| adrenal gland | 52% | 1.06 | 135 / 258 | 0% | 0.00 | 1 / 230 |
| liver | 51% | 1.46 | 116 / 226 | 1% | 0.02 | 5 / 406 |
| brain | 48% | 1.35 | 1267 / 2642 | 2% | 0.17 | 17 / 705 |
| pancreas | 43% | 1.04 | 141 / 328 | 4% | 1.70 | 8 / 178 |
| heart | 38% | 0.79 | 323 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 0.53 | 6 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008150 | Biological process | biological_process |
| GO_0031507 | Biological process | heterochromatin formation |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0000786 | Cellular component | nucleosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0031492 | Molecular function | nucleosomal DNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0030527 | Molecular function | structural constituent of chromatin |
| GO_0003674 | Molecular function | molecular_function |
| Gene name | H2AC21 |
| Protein name | Histone H2A type 2-B (H2A-clustered histone 21) |
| Synonyms | HIST2H2AB |
| Description | FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Accessions | Q8IUE6 ENST00000331128.6 |