H2AB2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H2AB2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H2AB2 at tissue level.

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0031507Biological processheterochromatin formation
GO_0006334Biological processnucleosome assembly
GO_0000791Cellular componenteuchromatin
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0030527Molecular functionstructural constituent of chromatin
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031492Molecular functionnucleosomal DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameH2AB2
Protein nameHistone H2A-Bbd type 2/3 (H2A Barr body-deficient) (H2A.Bbd)
SynonymsH2AFB
H2AFB2;
H2AB3
H2AFB3
H2ABBD
DescriptionFUNCTION: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. .

AccessionsENST00000615853.1
ENST00000354514.6
P0C5Z0