GUCY2D | OmnibusX

Name	Number of supported studies	Average coverage
retinal rod cell	3 studies	25% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GUCY2D at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	93%	44.18	229 / 245	53%	1.47	265 / 502
thymus	94%	18.05	617 / 653	32%	0.58	192 / 605
lung	81%	26.89	468 / 578	22%	0.44	251 / 1155
breast	79%	16.07	364 / 459	20%	0.45	225 / 1118
skin	93%	14.80	1684 / 1809	2%	0.05	11 / 472
spleen	86%	11.03	208 / 241	0%	0	0 / 0
pancreas	79%	7.77	260 / 328	7%	0.11	12 / 178
stomach	79%	13.22	283 / 359	2%	0.04	6 / 286
brain	78%	9.98	2063 / 2642	1%	0.02	10 / 705
kidney	72%	8.80	64 / 89	7%	0.11	66 / 901
bladder	57%	3.86	12 / 21	11%	0.22	53 / 504
esophagus	58%	21.52	841 / 1445	8%	0.15	15 / 183
liver	53%	4.30	119 / 226	13%	0.30	53 / 406
adipose	62%	6.59	744 / 1204	0%	0	0 / 0
intestine	60%	6.26	576 / 966	2%	0.03	11 / 527
ovary	57%	8.32	102 / 180	2%	0.03	9 / 430
peripheral blood	58%	10.20	539 / 929	0%	0	0 / 0
heart	58%	5.94	498 / 861	0%	0	0 / 0
uterus	45%	4.55	76 / 170	7%	0.12	31 / 459
adrenal gland	33%	2.14	85 / 258	3%	0.06	8 / 230
blood vessel	29%	2.20	383 / 1335	0%	0	0 / 0
muscle	13%	0.89	108 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.45	4 / 80
tonsil	0%	0	0 / 0	2%	0.03	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0019934	Biological process	cGMP-mediated signaling
GO_0007601	Biological process	visual perception
GO_0006182	Biological process	cGMP biosynthetic process
GO_0007168	Biological process	receptor guanylyl cyclase signaling pathway
GO_0022400	Biological process	regulation of opsin-mediated signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0001750	Cellular component	photoreceptor outer segment
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005640	Cellular component	nuclear outer membrane
GO_0097381	Cellular component	photoreceptor disc membrane
GO_0042622	Cellular component	photoreceptor outer segment membrane
GO_0042803	Molecular function	protein homodimerization activity
GO_0004016	Molecular function	adenylate cyclase activity
GO_0038023	Molecular function	signaling receptor activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0001653	Molecular function	peptide receptor activity
GO_0004672	Molecular function	protein kinase activity
GO_0005525	Molecular function	GTP binding
GO_0005524	Molecular function	ATP binding
GO_0004383	Molecular function	guanylate cyclase activity
GO_0005515	Molecular function	protein binding

Gene name	GUCY2D
Protein name	Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (CG-E) (Guanylate cyclase 2D, retinal) (Rod outer segment membrane guanylate cyclase) (ROS-GC)
Synonyms	RETGC1 CORD6 RETGC GUC1A4 GUC2D
Description	FUNCTION: Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment . May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). .
Accessions	ENST00000254854.5 Q02846

GUCY2D report