GUCA1B | OmnibusX

Name	Number of supported studies	Average coverage
retinal cone cell	8 studies	63% ± 24%	Explore
retinal rod cell	6 studies	47% ± 15%	Explore

Name	Number of supported studies	Average coverage
eye	5 studies	35% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	97%	102.00	2566 / 2642	96%	5.00	675 / 705
prostate	100%	87.35	244 / 245	88%	2.16	442 / 502
breast	99%	87.44	456 / 459	79%	2.39	881 / 1118
adrenal gland	93%	50.37	239 / 258	79%	2.37	182 / 230
uterus	100%	139.64	170 / 170	70%	1.87	320 / 459
lung	98%	64.12	569 / 578	63%	1.61	728 / 1155
thymus	98%	61.68	639 / 653	62%	1.81	377 / 605
bladder	95%	61.29	20 / 21	62%	1.56	312 / 504
pancreas	76%	24.72	249 / 328	79%	1.86	141 / 178
intestine	99%	70.05	953 / 966	52%	1.07	273 / 527
liver	94%	51.35	213 / 226	56%	1.25	228 / 406
kidney	93%	44.64	83 / 89	57%	1.41	514 / 901
esophagus	94%	53.01	1362 / 1445	56%	1.23	102 / 183
ovary	100%	137.79	180 / 180	50%	1.12	213 / 430
skin	91%	84.62	1654 / 1809	56%	1.52	266 / 472
stomach	90%	36.43	324 / 359	40%	0.84	113 / 286
spleen	100%	111.99	240 / 241	0%	0	0 / 0
adipose	98%	69.93	1176 / 1204	0%	0	0 / 0
muscle	97%	67.32	782 / 803	0%	0	0 / 0
blood vessel	96%	54.49	1283 / 1335	0%	0	0 / 0
heart	95%	48.51	820 / 861	0%	0	0 / 0
peripheral blood	77%	35.05	712 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	69%	1.55	20 / 29
eye	0%	0	0 / 0	64%	12.80	51 / 80
tonsil	0%	0	0 / 0	51%	1.07	23 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007168	Biological process	receptor guanylyl cyclase signaling pathway
GO_0007589	Biological process	body fluid secretion
GO_0007601	Biological process	visual perception
GO_0031282	Biological process	regulation of guanylate cyclase activity
GO_0007267	Biological process	cell-cell signaling
GO_0097381	Cellular component	photoreceptor disc membrane
GO_0001917	Cellular component	photoreceptor inner segment
GO_0120199	Cellular component	cone photoreceptor outer segment
GO_0005886	Cellular component	plasma membrane
GO_0005509	Molecular function	calcium ion binding
GO_0008048	Molecular function	calcium sensitive guanylate cyclase activator activity
GO_0005515	Molecular function	protein binding

Gene name	GUCA1B
Protein name	Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B) GUCA1B protein
Synonyms	GCAP2
Description	FUNCTION: Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). .
Accessions	A4FUA1 Q9UMX6 ENST00000230361.4

GUCA1B report