GSX2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GSX2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GSX2 at tissue level.

III. Associated gene sets

GO_0002087Biological processregulation of respiratory gaseous exchange by nervous system process
GO_0021527Biological processspinal cord association neuron differentiation
GO_0021575Biological processhindbrain morphogenesis
GO_0007219Biological processNotch signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0021978Biological processtelencephalon regionalization
GO_0048665Biological processneuron fate specification
GO_0021798Biological processforebrain dorsal/ventral pattern formation
GO_0097154Biological processGABAergic neuron differentiation
GO_0060163Biological processsubpallium neuron fate commitment
GO_0030334Biological processregulation of cell migration
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0021889Biological processolfactory bulb interneuron differentiation
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0048853Biological processforebrain morphogenesis
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding

IV. Literature review

[source]
Gene nameGSX2
Protein nameGS homeobox 2
GS homeobox 2 (Genetic-screened homeobox 2) (Homeobox protein GSH-2)
SynonymsGSH2
DescriptionFUNCTION: Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development . During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). .

AccessionsQ9BZM3
D6R903
ENST00000503800.1
B2LYG3
ENST00000326902.7