GSTA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901687Biological processglutathione derivative biosynthetic process
GO_0006805Biological processxenobiotic metabolic process
GO_0098869Biological processcellular oxidant detoxification
GO_0043651Biological processlinoleic acid metabolic process
GO_0006693Biological processprostaglandin metabolic process
GO_0006749Biological processglutathione metabolic process
GO_0030855Biological processepithelial cell differentiation
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0004769Molecular functionsteroid delta-isomerase activity
GO_0005504Molecular functionfatty acid binding
GO_0004602Molecular functionglutathione peroxidase activity
GO_0004364Molecular functionglutathione transferase activity

IV. Literature review

[source]
Gene nameGSTA1
Protein nameGlutathione S-transferase A1 (EC 2.5.1.18) (13-hydroperoxyoctadecadienoate peroxidase) (EC 1.11.1.-) (Androst-5-ene-3,17-dione isomerase) (EC 5.3.3.-) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed]
Synonyms
DescriptionFUNCTION: Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) . It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis . Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid . .

AccessionsP08263
ENST00000334575.6