GSPT2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GSPT2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GSPT2 at tissue level.

III. Associated gene sets

GO_0006412Biological processtranslation
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0006415Biological processtranslational termination
GO_0018444Cellular componenttranslation release factor complex
GO_0005829Cellular componentcytosol
GO_0005525Molecular functionGTP binding
GO_0003924Molecular functionGTPase activity
GO_0005515Molecular functionprotein binding
GO_0003747Molecular functiontranslation release factor activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameGSPT2
Protein nameEukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog)
SynonymsERF3B
DescriptionFUNCTION: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA . GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site . GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site . Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons . .

AccessionsENST00000340438.6
Q8IYD1