GSDMA | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of GSDMA at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	49%	71.25	712 / 1445	71%	9.15	130 / 183
bladder	48%	27.33	10 / 21	71%	3.82	356 / 504
skin	73%	3711.26	1319 / 1809	42%	4.39	196 / 472
intestine	35%	21.80	340 / 966	77%	5.36	407 / 527
lung	43%	32.45	250 / 578	61%	2.37	705 / 1155
breast	42%	37.42	192 / 459	51%	1.35	569 / 1118
stomach	12%	6.54	43 / 359	77%	4.75	220 / 286
kidney	43%	25.33	38 / 89	35%	0.94	315 / 901
thymus	15%	9.39	96 / 653	62%	2.32	374 / 605
uterus	23%	18.52	39 / 170	49%	1.89	223 / 459
tonsil	0%	0	0 / 0	67%	4.48	30 / 45
pancreas	4%	3.31	14 / 328	61%	2.14	108 / 178
adipose	65%	97.62	780 / 1204	0%	0	0 / 0
adrenal gland	44%	34.89	114 / 258	11%	0.25	26 / 230
lymph node	0%	0	0 / 0	45%	1.48	13 / 29
ovary	8%	3.50	14 / 180	33%	0.74	144 / 430
brain	1%	0.57	35 / 2642	39%	1.45	272 / 705
spleen	33%	16.24	80 / 241	0%	0	0 / 0
blood vessel	28%	26.23	376 / 1335	0%	0	0 / 0
liver	4%	2.19	8 / 226	13%	0.30	52 / 406
peripheral blood	16%	11.20	149 / 929	0%	0	0 / 0
heart	13%	7.29	108 / 861	0%	0	0 / 0
prostate	2%	1.33	6 / 245	10%	0.17	50 / 502
eye	0%	0	0 / 0	6%	0.09	5 / 80
muscle	5%	4.19	39 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0070269	Biological process	pyroptotic inflammatory response
GO_0055085	Biological process	transmembrane transport
GO_0042742	Biological process	defense response to bacterium
GO_0005829	Cellular component	cytosol
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005546	Molecular function	phosphatidylinositol-4,5-bisphosphate binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0005515	Molecular function	protein binding
GO_0070273	Molecular function	phosphatidylinositol-4-phosphate binding
GO_0022829	Molecular function	wide pore channel activity

Gene name	GSDMA
Protein name	Gasdermin-A (Gasdermin-1) [Cleaved into: Gasdermin-A, N-terminal (GSDMA-NT); Gasdermin-A, C-terminal (GSDMA-CT)] Gasdermin A
Synonyms	FKSG9 GSDM1 GSDM
Description	FUNCTION: [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon infection by S.pyogenes, specifically cleaved by S.pyogenes effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. .; FUNCTION: [Gasdermin-A, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis . Released upon cleavage by S.pyogenes effector protein SpeB, and binds to membrane inner leaflet lipids . Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . Pyroptosis triggers the elimination of the infected skin cell, depriving the pathogen of its protective niche, while inducing an inflammatory response . This ultimately prevents bacterial penetration of the epithelial barrier and a subsequent systemic dissemination of the pathogen . Binds to cardiolipin and other acidic phospholipids, such as phosphatidylserine, which mediate its targeting to the inner leaflet membrane . .
Accessions	ENST00000635792.1 J3KRG2 ENST00000577447.1 Q96QA5 ENST00000301659.9

GSDMA report