GRIN2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097553Biological processcalcium ion transmembrane import into cytosol
GO_0019722Biological processcalcium-mediated signaling
GO_0007611Biological processlearning or memory
GO_0060079Biological processexcitatory postsynaptic potential
GO_0035235Biological processionotropic glutamate receptor signaling pathway
GO_0098976Biological processexcitatory chemical synaptic transmission
GO_0060291Biological processlong-term synaptic potentiation
GO_0045471Biological processresponse to ethanol
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_0099505Biological processregulation of presynaptic membrane potential
GO_0048167Biological processregulation of synaptic plasticity
GO_1904062Biological processregulation of monoatomic cation transmembrane transport
GO_0048168Biological processregulation of neuronal synaptic plasticity
GO_2001056Biological processpositive regulation of cysteine-type endopeptidase activity
GO_0007268Biological processchemical synaptic transmission
GO_0098655Biological processmonoatomic cation transmembrane transport
GO_0051290Biological processprotein heterotetramerization
GO_0007420Biological processbrain development
GO_0051968Biological processpositive regulation of synaptic transmission, glutamatergic
GO_1902951Biological processnegative regulation of dendritic spine maintenance
GO_0007215Biological processglutamate receptor signaling pathway
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0098839Cellular componentpostsynaptic density membrane
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0097060Cellular componentsynaptic membrane
GO_0005764Cellular componentlysosome
GO_0043005Cellular componentneuron projection
GO_0009986Cellular componentcell surface
GO_0014069Cellular componentpostsynaptic density
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0045211Cellular componentpostsynaptic membrane
GO_0017146Cellular componentNMDA selective glutamate receptor complex
GO_1904315Molecular functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0004972Molecular functionNMDA glutamate receptor activity
GO_0001540Molecular functionamyloid-beta binding
GO_0016595Molecular functionglutamate binding
GO_0008270Molecular functionzinc ion binding
GO_0016594Molecular functionglycine binding
GO_0099507Molecular functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0022849Molecular functionglutamate-gated calcium ion channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGRIN2B
Protein nameGlutamate receptor
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
Glutamate ionotropic receptor NMDA type subunit 2B
SynonymsNMDAR2B
hCG_1811072
DescriptionFUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) . Sensitivity to glutamate and channel kinetics depend on the subunit composition . In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity). .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

AccessionsA0A8D9PHB2
A0A0D9SFK0
ENST00000630791.2
ENST00000609686.4
Q13224
ENST00000627535.2
ENST00000637214.1
A0A0D9SFA0
A0A1B0GU78