GRIA4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	16 studies	65% ± 20%	Explore
oligodendrocyte	15 studies	41% ± 17%	Explore
glutamatergic neuron	13 studies	67% ± 20%	Explore
GABAergic neuron	11 studies	65% ± 21%	Explore
astrocyte	11 studies	37% ± 19%	Explore
amacrine cell	8 studies	74% ± 23%	Explore
retina horizontal cell	7 studies	88% ± 10%	Explore
interneuron	7 studies	62% ± 24%	Explore
retinal ganglion cell	7 studies	73% ± 21%	Explore
neuron	5 studies	52% ± 13%	Explore
microglial cell	5 studies	30% ± 14%	Explore
endothelial cell	4 studies	45% ± 21%	Explore
granule cell	4 studies	73% ± 13%	Explore
glycinergic amacrine cell	4 studies	70% ± 31%	Explore
Mueller cell	4 studies	74% ± 11%	Explore
OFF-bipolar cell	4 studies	39% ± 25%	Explore
macrophage	3 studies	24% ± 7%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	64% ± 6%	Explore
GABAergic interneuron	3 studies	69% ± 3%	Explore
GABAergic amacrine cell	3 studies	93% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	48% ± 20%	Explore
eye	5 studies	28% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	4426.13	2628 / 2642	97%	59.71	684 / 705
adrenal gland	12%	78.31	31 / 258	60%	10.88	137 / 230
stomach	65%	439.23	232 / 359	0%	0	0 / 286
intestine	53%	240.06	510 / 966	0%	0.01	1 / 527
breast	33%	199.15	153 / 459	5%	0.29	60 / 1118
kidney	8%	27.79	7 / 89	30%	3.92	274 / 901
skin	6%	17.67	101 / 1809	6%	1.28	27 / 472
pancreas	8%	24.72	26 / 328	3%	0.25	5 / 178
uterus	7%	31.32	12 / 170	2%	0.16	8 / 459
eye	0%	0	0 / 0	3%	0.15	2 / 80
ovary	1%	2.87	2 / 180	1%	0.09	5 / 430
blood vessel	2%	6.75	26 / 1335	0%	0	0 / 0
esophagus	1%	2.83	10 / 1445	1%	0.05	2 / 183
prostate	0%	0	0 / 245	1%	0.27	6 / 502
lung	0%	0	0 / 578	1%	0.09	10 / 1155
liver	0%	0	0 / 226	0%	0.01	2 / 406
bladder	0%	0	0 / 21	0%	0.03	2 / 504
heart	0%	0.60	2 / 861	0%	0	0 / 0
thymus	0%	0	0 / 653	0%	0.20	1 / 605
adipose	0%	0.34	1 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0035235	Biological process	ionotropic glutamate receptor signaling pathway
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0034392	Biological process	negative regulation of smooth muscle cell apoptotic process
GO_0099505	Biological process	regulation of presynaptic membrane potential
GO_0060078	Biological process	regulation of postsynaptic membrane potential
GO_0007215	Biological process	glutamate receptor signaling pathway
GO_0035249	Biological process	synaptic transmission, glutamatergic
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0030666	Cellular component	endocytic vesicle membrane
GO_1903561	Cellular component	extracellular vesicle
GO_0032281	Cellular component	AMPA glutamate receptor complex
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_1904315	Molecular function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0001540	Molecular function	amyloid-beta binding
GO_0004970	Molecular function	glutamate-gated receptor activity
GO_0004971	Molecular function	AMPA glutamate receptor activity
GO_0099507	Molecular function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

IV. Literature review

[source]

Gene name	GRIA4
Protein name	Glutamate receptor AMPA-selective glutamate receptor 4 GluA4-ATD Glutamate ionotropic receptor AMPA type subunit 4 Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) GRIA4 protein Glutamate receptor 4 variant
Synonyms	GLUR4 hCG_2032458
Description	FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .
Accessions	ENST00000703743.2 A6QL61 ENST00000525921.1 P48058 E9PR13 ENST00000531986.5 ENST00000531011.5 ENST00000393125.6 [P48058-2] ENST00000428631.6 [P48058-2] ENST00000527177.5 ENST00000525187.6 E9PQY1 G8HBB0 C5IJI4 A0A8D9PH77 ENST00000282499.10 [P48058-1] H0YDL4 G3V164 ENST00000706777.1 ENST00000527669.1 Q1WWK6 ENST00000530497.1 [P48058-1] A0A994J6J2 E9PJZ5 ENST00000525942.1

GRIA4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review