GRIA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0019722Biological processcalcium-mediated signaling
GO_0035235Biological processionotropic glutamate receptor signaling pathway
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0060291Biological processlong-term synaptic potentiation
GO_0099505Biological processregulation of presynaptic membrane potential
GO_0051290Biological processprotein heterotetramerization
GO_0060078Biological processregulation of postsynaptic membrane potential
GO_0007215Biological processglutamate receptor signaling pathway
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0051289Biological processprotein homotetramerization
GO_0098839Cellular componentpostsynaptic density membrane
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0030666Cellular componentendocytic vesicle membrane
GO_0032281Cellular componentAMPA glutamate receptor complex
GO_0045211Cellular componentpostsynaptic membrane
GO_0098688Cellular componentparallel fiber to Purkinje cell synapse
GO_1904315Molecular functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0001540Molecular functionamyloid-beta binding
GO_0004970Molecular functionglutamate-gated receptor activity
GO_0004971Molecular functionAMPA glutamate receptor activity
GO_0099507Molecular functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0022849Molecular functionglutamate-gated calcium ion channel activity

IV. Literature review

[source]
Gene nameGRIA3
Protein nameGlutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3)
Glutamate receptor
Glutamate ionotropic receptor AMPA type subunit 3 (Glutamate receptor, ionotrophic, AMPA 3)
SynonymsGLUR3
GLURC
DescriptionFUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .

AccessionsENST00000620581.4
ENST00000616590.4
P42263
Q9P0H2
Q17R51
ENST00000620443.2 [P42263-2]
ENST00000611689.4
ENST00000622768.5 [P42263-1]
Q5XKG2
A0A087WYJ6