GPR3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR3 at tissue level.

III. Associated gene sets

GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0043950Biological processpositive regulation of cAMP-mediated signaling
GO_0040020Biological processregulation of meiotic nuclear division
GO_0019222Biological processregulation of metabolic process
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPR3
Protein nameG protein-coupled receptor 3
G-protein coupled receptor 3 (ACCA orphan receptor)
SynonymsACCA
DescriptionFUNCTION: Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand . Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (By similarity). .

AccessionsP46089
F1DAM5
ENST00000374024.4