GPR137B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006914Biological processautophagy
GO_0043030Biological processregulation of macrophage activation
GO_0010506Biological processregulation of autophagy
GO_0043087Biological processregulation of GTPase activity
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0150032Biological processpositive regulation of protein localization to lysosome
GO_0045779Biological processnegative regulation of bone resorption
GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPR137B
Protein nameIntegral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein)
G protein-coupled receptor 137B
SynonymsTM7SF1
DescriptionFUNCTION: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome . Involved in the regulation of lysosomal morphology and autophagy . .; FUNCTION: Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity). .

AccessionsENST00000454895.2
ENST00000419162.5
Q5TAF0
O60478
ENST00000366592.8
H0Y509