GPHA2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPHA2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPHA2 at tissue level.

III. Associated gene sets

GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005179Molecular functionhormone activity
GO_0031531Molecular functionthyrotropin-releasing hormone receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPHA2
Protein nameGlycoprotein hormone subunit alpha 2
Glycoprotein hormone alpha 2, isoform CRA_a (Glycoprotein-alpha 2)
Glycoprotein hormone alpha-2 (Putative secreted protein Zsig51) (Thyrostimulin subunit alpha)
SynonymshCG_23404
GPA2
ZSIG51
DescriptionFUNCTION: Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production . Plays a central role in controlling thyroid cell metabolism . .

AccessionsENST00000533257.1
ENST00000279168.7
Q96T91
ENST00000532246.1
E9PLQ0
A0A024R579